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Cruciferous vegetables, including broccoli, cauliflower, Brussels sprouts, and cabbage, contain a compound called indole-3-carbinol (I3C).* As a nutritional supplement, I3C provides key nutritional support for the liver's detoxification of estrogens, thus playing an important role in supporting female reproductive health.* A large portion of I3C is converted to diindolylmethane (DIM), the substance believed to be the primary contributor to I3C's beneficial properties. DIM has been shown to selectively bind to estrogen receptors and might act as an estrogen antagonist.*